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The first issues of Deadly Class focus on the story of teenage orphan Marcus Lopez Arguello as he transitions from living on the streets to being enrolled into a school of assassins. The academy, run by Master Lin, is composed of children of mob bosses and mass murderers, learning the same trade as their parents. Marcus's decision to attend the school is one of the only decisions he gets to make for himself throughout the arc and history. His entire life has been composed of unfortunate events, each leaving him further ostracized from humanity. Marcus is homeless largely because his parents died in a horrible accident when he was young, leaving him in an orphanage whose headmaster required his manual labor for him to retain residence. This continued degradation of his sanity through the abuse by the hands of his roommates and guardians eventually drives him to committing a massive act of violence. Deadly Class then follows the students in the academy and many of their eventual downfalls.
The Isles of Los Angeles 2089: Humanity is addicted to technology, a population of unemployed leisure seekers blissfully distracted from toxic contamination, who borrow, steal, and kill to buy their next digital fix. Getting a virtual buzz is the only thing left to live for. It's the biggest industry, the only industry, the drug everyone needs, and gangsters run it all. And who do these gangsters turn to when they need their rule enforced? Constables Led Dent and Debbie Decay. This duo is about to be given a job that will force them out of the familiar squalor of Los Angeles to take down the last tech-less country on Earth: The Garden Nation of Tokyo.